Churg-Strauss syndrome associated with elevated levels of serum interleukin-5 and T cell receptor-Cβ gene rearrangement.

نویسندگان

  • Yoshiro Horai
  • Tomoya Miyamura
  • Soichiro Takahama
  • Akie Hirata
  • Masataka Nakamura
  • Hitoshi Ando
  • Rumi Minami
  • Masahiro Yamamoto
  • Eiichi Suematsu
چکیده

A 58-year-old woman was diagnosed with Churg-Strauss syndrome (CSS) based on the symptoms of bronchial asthma, eosinophilia, mononeuritis multiplex and histological examination of the right sural nerve. Prior to treatment, the serum interleukin (IL)-5 level was high, and rearrangement of the T cell receptor (TCR) gene was identified. This is the first report of TCR gene rearrangement in a patient with CSS. The expanded T cell clone may be responsible for the overproduction of IL-5. Further studies are warranted to disclose a prevalence of TCR gene rearrangement in CSS patients and its pathophysiological roles in the development of this disease.

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عنوان ژورنال:
  • Modern rheumatology

دوره 21 1  شماره 

صفحات  -

تاریخ انتشار 2011